Table of Contents
What is the difference between ligand based and structure based drug design?
When there is a natural ligand present in a protein, the features of that protein or already proposed ligands’ features are used to design a new ligand that has more affinity than the existing ones is said to be Ligand based while proposing new ligands/small molecules on the basis of binding pocket or hot spot …
What is the main goal of the fragment based drug discovery approach?
Fragment-based drug discovery (FBDD) is a new approach, increasingly used in the pharmaceutical industry, for reducing attrition and providing leads for previously intractable biological targets. FBDD identifies low-molecular-weight ligands (∼150 Da) that bind to biologically important macromolecules.
What is the difference between drug design and drug discovery?
Despite advances in biotechnology and understanding of biological systems, drug discovery is still a lengthy, costly, difficult, and inefficient process with a high attrition rate of new therapeutic discovery. Drug design is the inventive process of finding new medications based on the knowledge of a biological target.
Which of the following is structure based drug design technique?
There are three primary methods for structure determination that are useful for drug design: X-ray crystallography, NMR, and homology modeling. The evaluation of structures from each method will be discussed.
Which of the following approaches is under ligand based drug designing?
Basics of QSAR The most popular approaches for ligand-based drug design are the QSAR method and pharmacophore modeling. QSAR is a computational method to quantify the correlation between the chemical structures of a series of compounds and a particular chemical or biological process.
What is fragment based drug design or discovery and how is it used to develop new pharmaceuticals?
What are the advantages of fragment based chemistry?
The key advantage of fragments is their low degree of complexity. Actually, these scaffolds should hit a sweet spot, which enables them to still be big enough to undergo a few directed attractive interactions with the protein of interest so that biophysical detection of target binding is possible.
When structurally different drugs give same clinical results it is called?
A. Therapeutic equivalence.
What is meant by drug discovery?
Definition. Drug discovery is the process through which potential new medicines are identified. It involves a wide range of scientific disciplines, including biology, chemistry and pharmacology.
What is target-based drug discovery?
Recombinant technology and genomics enabled target-based drug discovery, using methods engineered with defined molecular targets. In phenotypic screening, drugs are identified without knowledge of or bias toward a specific molecular target, first identifying their pharmacological actions in cells, tissues, or animals.
What are the two major approaches to drug discovery?
The two major CADD-based approaches are structure-based drug design, where protein structures are required, and ligand-based drug design, where ligand and ligand activities can be used to design compounds interacting with the protein structure.