Table of Contents
What is the most common cause of thrombocytosis?
Essential thrombocythemia (ET) was the most common cause of primary thrombocytosis. Among secondary, non-infectious etiologies, tissue damage was the most common, followed by malignancy and iron-deficiency anemia. The most common infectious causes of thrombocytosis were soft-tissue, pulmonary and GI infections.
Is thrombocytosis serious?
Primary thrombocytosis, or essential thrombocythemia, can cause serious bleeding or clotting complications. These can usually be avoided by maintaining good control of the platelet count with medications. After many years of having the disease, however, bone marrow fibrosis (scarring) can develop.
Is secondary thrombocytosis a cancer?
[6] Even though secondary thrombocytosis is benign, the underlying etiology of thrombocytosis (e.g., malignancy, connective tissue disorders, chronic infections) can be associated with an increased risk of adverse outcomes.
Can chronic inflammation cause thrombocytosis?
[5] Reactive causes of thrombocytosis include transient processes such as acute blood loss, acute infection, or sustained forms of reactive thrombocytosis include iron deficiency, asplenia, cancer, chronic inflammatory, or infectious diseases.
Can MS cause high platelets?
Early Evidence of Platelet Involvement in MS Subsequently, multiple studies demonstrated increased platelet adhesiveness in MS, relative to other neurological disorders, both in the percentage of patients exhibiting abnormalities in adhesiveness and in the extent of the differences.
What cancers cause high platelets?
Cancers of the colon, stomach, lung, breast and ovary and lymphoma are associated with increased platelet counts. Notably, the presence of an elevated platelet count is often an indicator of poor long-term prognosis among people with cancer. People with iron-deficiency or hemolytic anemia may have secondary thrombocytosis.
Is essential thrombocytosis fatal?
One of the myoproliferative diseases known as essential thrombocytosis (aka essential thrombocythemia, and essential thrombocythaemia) is a potentially fatal condition that involves the overproduction of blood platelets.
What is thrombocytosis HCC?
Thrombocytosis is a paraneoplastic syndrome of HCC patients due to the overproduction of TPO by HCC. It is frequently associated with a large tumor volume and high serum alpha-fetoprotein.