Sage-Tips

What does it mean when you are HBsAg positive and HBeAg negative?

In HBV carriers and patients with chronic hepatitis B, positive HBeAg results usually indicate presence of active HBV replication and high infectivity. A negative HBeAg result indicates very minimal or no HBV replication. Positive anti-HBe results usually indicate inactivity of the virus and low infectivity.

What is HBeAg negative?

Hepatitis B e antigen (HBeAg)‐negative CHB is also referred to as anti‐HBe‐positive and precore mutant hepatitis. Patients with HBeAg‐negative CHB have a naturally occurring mutant form of HBV that does not produce HBeAg because of a mutation in the precore or core promoter region of the HBV genome.

When a patient is HBsAg negative and anti HBs positive What is the status of his or her hepatitis B infection?

HBsAg. If negative, acute HBV infection is ruled out (15). If positive, the patient is infected with HBV. A repeat test after six months will determine if the infection has resolved or is chronic.

What is the treatment for HBeAg negative?

The most common antiviral treatments are either entecavir (Baraclude) or tenofovir (Viread). These two are considered the most powerful at quickly reducing viral load (HBV DNA) and have a very low risk of causing drug resistance, which is critical considering the long-term treatment required by HBeAg-negative patients.

How long people who were HBeAg negative when they started antivirals should remain on treatment?

EASL guidelines say non-cirrhotic, HBeAg-negative patients who have had at least three years of antiviral treatment, undetectable viral load and no signs of liver damage can stop treatment, as long as there is frequent follow-up monitoring.

What is if HBeAg positive?

What HBeAg Test Results Mean. A positive test for the hepatitis B e-antigen means that there is an active infection with the hepatitis B virus and the virus is actively multiplying. Anyone who is in contact with your blood without protection may be at risk of contracting hepatitis B from you.

What test confirms HBV?

The “Hepatitis B Panel” of Blood Tests HBsAg (Hepatitis B surface antigen) – A “positive” or “reactive” HBsAg test result means that the person is infected with hepatitis B. This test can detect the actual presence of the hepatitis B virus (called the “surface antigen”) in your blood.

What is HBsAg test?

Hepatitis B surface antigen (HBsAg) is a blood test ordered to determine if someone is infected with the hepatitis B virus. If it is found, along with specific antibodies, it means the person has a hepatitis B infection.

What does HBsAg reactive?

HBsAg (Hepatitis B surface antigen) – A “positive” or “reactive” HBsAg test result means that the person is infected with hepatitis B. This test can detect the actual presence of the hepatitis B virus (called the “surface antigen”) in your blood.

What does HBsAg mean in blood work?

Hepatitis B surface antigen (HBsAg): A protein on the surface of hepatitis B virus; it can be detected in high levels in serum during acute or chronic hepatitis B virus infection. The presence of HBsAg indicates that the person is infectious.

What is the management of HBsAg positive patients?

Management of HBsAg Positive Patients. Patients who are HBsAg positive should be assessed as follows: Virologic and hepatic status. Clinical history (including family history) should be taken, in particular looking for evidence of symptomatic liver disease in the patient, family, or household member.

What serologic tests are needed to diagnose hepatitis B (HB)?

Three different serologic tests are needed (hepatitis B surface antigen [HBsAg], hepatitis B surface antibody [anti-HBs], and total hepatitis B core antibody [anti-HBc]) to determine whether a patient

What does HBA positive mean on a blood test?

A positive or “reactive” test indicates that a person may have been infected with the hepatitis B virus at some point in time. This test is often used by blood banks to screen blood donation, however, all three test results are needed to make a diagnosis. Interpretation and Action Needed HBsAg HBsAb HBcAb