Table of Contents
What do you mean by lead compounds?
(leed KOM-pownd) In medicine, a chemical compound that shows promise as a treatment for a disease and may lead to the development of a new drug. Thousands of compounds are tested in the laboratory to find a lead (“leading”) compound that may act on specific genes or proteins involved in a disease.
What is lead compound and example?
A lead compound (/ˈliːd/, i.e. a “leading” compound, not to be confused with various compounds of the metallic element lead) in drug discovery is a chemical compound that has pharmacological or biological activity likely to be therapeutically useful, but may nevertheless have suboptimal structure that requires …
How are lead compounds formed?
Lead occurs naturally in the earth’s crust. It is also found in combined form in several minerals: galena, anglesite, pyromorphite and mimetite. Lead may be released as particles into the atmosphere or as dissolved compounds in water. Lead is also released from natural sources such as windblown dusts and forest fires.
What is molecular modification in drug design?
Molecular modification is chemical alteration of a known and previously characterized lead compound for the purpose of enhancing its usefulness as a drug.
What is lead modification?
The goal of medicinal chemistry in the drug discovery process is to uncover new drug candidates, before advancing to clinical trials and drug development. Several parameters must be improved upon before it can be deemed fit for pre-clinical and clinical trials. …
What are some lead compounds?
Lead is present in a variety of compounds such as lead acetate, lead chloride, lead chromate, lead nitrate, and lead oxide. (
What is drug modification?
Drug action can be modified in a number of ways ; by altering its physical properties by adding to it other substances or other drugs, or by modifying its chemical structure.
What is lead Optimisation?
Definition. Lead optimization is the process by which a drug candidate is designed after an initial lead compound is identified.
What products use lead?
Lead and lead compounds have been used in a wide variety of products found in and around our homes, including paint, ceramics, pipes and plumbing materials, solders, gasoline, batteries, ammunition and cosmetics.
What is the meaning of lead compound?
A lead compound ( /ˈliːd/, i.e. a “leading” compound, not to be confused with various compounds of the metallic element lead) in drug discovery is a chemical compound that has pharmacological or biological activity likely to be therapeutically useful, but may nevertheless have suboptimal structure…
How can molecular modification enhance the solubility of a lead compound?
Molecular modification is used to enhance drug’s water solubility by incorporating water solubilizing groups in its structure. The discussion of the introduction of water solubilizing groups into the structure of a lead compound can be conveniently broken down into four general areas: The type of group introduced;
How can we improve the safety and efficacy of lead compounds?
Once a lead compound or ‘hit’ has been identified, modification and optimization is the next step. Improving its safety and efficacy profiles through rational drug design can strengthen its position as a drug candidate, improving its chances of it making it to market as a drug. This article is a continuation of our medicinal chemistry series.
What is molecular modification in pharmacology?
Molecular modification is chemical alteration of a known and previously characterized lead compound for the purpose of enhancing its usefulness as a drug. This could mean enhancing its specificity for a particular body target site, increasing its potency, improving its rate and extent of absorption,…