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What are the dangers of proton pump inhibitors?
Although PPIs have had an encouraging safety profile, recent studies regarding the long-term use of PPI medications have noted potential adverse effects, including risk of fractures, pneumonia, Clostridium difficile diarrhea, hypomagnesemia, vitamin B12 deficiency, chronic kidney disease, and dementia.
Are proton pump inhibitors bad for your heart?
Proton pump inhibitor use is independently associated with an increased incidence of heart failure and death. Proton pump inhibitors (PPIs) may increase the risk for heart failure and death, but not acute ischemic events, in patients with coronary artery disease (CAD), according to a study published in PLoS One.
Can proton pump inhibitors make reflux worse?
If a PPI is stopped, people who have been taking it may find they have even worse acid reflux than before. This happens because the PPIs are good at shutting down acid production.
Who should not take proton pump inhibitors?
PPI Drug Interactions
| DRUG INTERACTIONS | WHAT HAPPENS |
|---|---|
| Plavix (clopidogrel) – blood thinner | Omeprazole and esomeprazole block the enzyme CYP2C19. The enzyme is needed to activate clopidogrel. This can decrease the blood thinner’s presence in the blood. |
How long should you take a proton pump inhibitor?
PPIs are generally supposed to be taken for two to eight weeks, depending on the condition being treated. Doctors sometimes prescribe PPIs for a longer period of time. The U.S. Food and Drug Administration states that over-the-counter PPIs should only be taken for a single 14-day treatment once every four months.
Are PPI safe long term?
However recent studies have potentially linked long term use of PPIs to some systemic severe adverse effects like increased risk of osteoporosis-related fractures, Clostridium difficile infection, malabsorption of vitamins and minerals such as vitamin B12, calcium and iron, dementia, pneumonia, kidney disease, and …
Can PPI cause dementia?
Recent clinical studies have shown that proton pump inhibitors (PPIs) are associated with risk of dementia, including AD. However, a recent case-control study reported decreased risk of dementia.
Can you take omeprazole for years?
Keep in mind that omeprazole is only intended for short-term treatment of heartburn, GERD, and other gastrointestinal conditions. Long-term use is only advised for people with rare medical conditions that cause hypersecretion of stomach acid.
What are the side effects of proton pump inhibitors?
The Dangers of Proton Pump Inhibitors. Although generally assumed to be safe, recent studies have shown that they have numerous side effects, from an altered gut environment and impaired nutrient absorption to an increased risk for cardiovascular events, kidney disease, and dementia.
Are proton pump inhibitors (PPIs) safe?
Proton pump inhibitors (PPIs) are widely used, and concerns about overuse have been raised. Therefore, side effects are important to be aware of and several suggested side effects of long-term use have been studied.
How do proton pump inhibitors affect bone health?
The effects of PPIs on bone health may be more nuanced than simply causing nutrient deficiency. Osteoclasts, the bone cells responsible for the resorption of calcium, also possess proton pumps, and their activity is thought to be directly affected by PPIs ( 18, 19 ). Several recent studies have also shed light on PPIs and the cardiovascular system.
What happens if you stop taking PPIs for GERD?
People taking PPIs for ulcer prophylaxis (with or without GERD symptoms) shouldn’t discontinue the medication without talking to a physician. A sudden stoppage could lead to an ulcer that bleeds or perforates, potentially causing further complications.
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