Table of Contents
- 1 How can you tell the difference between HUS and TTP?
- 2 What are the laboratory findings seen in TTP?
- 3 What is the difference between DIC and ITP?
- 4 Why is D dimer normal in TTP?
- 5 Which assessment findings indicate that a patient may be experiencing thrombotic thrombocytopenic purpura?
- 6 What is PT aPTT test?
- 7 What is ITP test?
- 8 Is ITP and TTP the same?
How can you tell the difference between HUS and TTP?
HUS is characterized by thrombocytopenia, anaemia and renal insufficiency, whereas the pentad of signs and symptoms including thrombocytopenia, anaemia, neurologic deficit, renal dysfunction and fever is observed in TTP.
What are the laboratory findings seen in TTP?
TTP patients usually present with a characteristic set of laboratory findings. This includes a negative direct antiglobulin test (DAT), microangiopathic hemolytic anemia (MAHA), and thrombocytopenia, which are considered major laboratory criterion of TTP.
Is PTT normal in TTP?
Prothrombin time (International Normalized Ratio) and activated partial thromboplastin time results typically are normal in both TTP and in hemolytic-uremic syndrome (HUS), although some series report patients with slight elevations on both tests.
What is the difference between DIC and ITP?
Thrombocytopenia is present in both DIC and immune thrombocytopenia (ITP). However, ITP is distinct from DIC in terms of its pathophysiologic mechanism and does not involve coagulation activation or microangiopathic hemolytic anemia.
Why is D dimer normal in TTP?
D-dimers are indicative of fibrinolysis and thus, thrombin activation, which usually is normal or mildly elevated in patients with TTP.
How is thrombocytopenic purpura diagnosis?
Complete blood count (CBC): Measures the size, number and maturity of different blood cells in a specific volume of blood (to measure platelets). Additional blood and urine tests: Measures bleeding time and detects possible infections. Includes a special blood test called an “anti-platelet antibody test.”
Which assessment findings indicate that a patient may be experiencing thrombotic thrombocytopenic purpura?
Complete blood count (CBC) findings in patients with thrombotic thrombocytopenic purpura (TTP) are usually as follows: Total white blood cell count is normal or slightly elevated. Hemoglobin concentration is moderately depressed at 8-9 g/dL. Platelet count generally ranges from 20,000-50,000/μL.
What is PT aPTT test?
The aPTT is one of several blood coagulation tests. It measures how long it takes your blood to form a clot. Normally, when one of your blood vessels is damaged, proteins in your blood called clotting factors come together in a certain order to form blood clots and quickly stop bleeding.
How do you test for DIC?
In clinical practice, a diagnosis of DIC can often be made by a combination of the following tests :
- Platelet count.
- Global clotting times (aPTT and PT)
- One or two clotting factors and inhibitors (eg, antithrombin)
- Assay for D-dimer or FDPs.
What is ITP test?
This test checks the number of red blood cells, white blood cells, and platelets in your blood. In ITP, the red and white blood cell counts are normal, but the platelet count is low. A blood smear. For this test, some of your blood is put on a slide. A microscope is used to look at your platelets and other blood cells.
Is ITP and TTP the same?
Are ITP and TTP the same thing? No, ITP and TTP are not the same thing. Both ITP and TTP are bleeding disorders, but they occur for different reasons and may require different treatments.