Table of Contents
Which of the following drug inhibit herpes virus?
The drugs approved since the introduction of ACV include valacyclovir (VACV, Valtrex®, the L-valine ester prodrug of ACV, penciclovir (PCV; [9-(4-hydroxy-3-hydroxymethylbutyl-1-yl) guanine]), a related nucleoside analogue with a similar basis for drug action against HSV and VZV, and its prodrug, famciclovir (FCV.
What inhibits viral DNA synthesis?
The guanosine depicted in this specific image is used for RNA synthesis but acyclovir inhibits the synthesis of DNA synthesis. One of the most often used antiviral drugs that works with the described mechanism is acyclovir (aciclovir), a guanosine analogue.
What are the inhibitors of DNA replication?
The first category includes purine and pyrmidine nucleoside analogs that directly inhibit DNA polymerase activity. The second category includes DNA damaging agents including cisplatin and chlorambucil that modify the composition and structure of the nucleic acid substrate to indirectly inhibit DNA synthesis.
Does acyclovir inhibit DNA polymerase?
Acyclovir triphosphate competitively inhibits viral DNA polymerase, and, to a much smaller extent, cellular DNA polymerases, with respect to deoxyguanosine triphosphate.
How Do antivirals work herpes?
Acyclovir is the antiviral most commonly used to treat HSV infections. It works by inhibiting DNA synthesis and therefore prevents replication of the virus. HSV-1 is transmitted by oral-to-oral contact, mainly causes oral herpes known as cold sores, and may also cause genital herpes.
What prevents viral replication?
Zinc, in particular, plays a key role in preventing virus replication, which is a critical component to a rapid and robust immune response to a viral infection.
What do PCR inhibitors do?
PCR inhibitors are any factor which prevent the amplification of nucleic acids through the polymerase chain reaction (PCR). PCR inhibitors usually affect PCR through interaction with DNA or interference with the DNA polymerase.
Which drug inhibit RNA and DNA synthesis?
Nucleic Acid Synthesis Inhibitors
| Drug | Drug Description |
|---|---|
| Rimantadine | An RNA synthesis inhibitor used to prevent influenza A infection. |
| Zidovudine | A dideoxynucleoside used in the treatment of HIV infection. |
| Foscarnet | An antiviral used to treat CMV, HIV, and HSV infections. |
What is acyclovir mechanism of action?
Mechanism of Action: Acyclovir is converted to its triphosphate form, acyclovir triphosphate (ACV-TP), which competitively inhibits viral DNA polymerase, incorporates into and terminates the growing viral DNA chain, and inactivates the viral DNA polymerase.
What enzyme does acyclovir inhibit?
Acyclovir triphosphate competitively inhibits viral DNA polymerase by acting as an analog to deoxyguanosine triphosphate (dGTP).
Which is a protease inhibitor?
Protease inhibitors are a class of antiretroviral medication that people use alongside other HIV drugs to manage HIV effectively. Protease inhibitors work by stopping the activity of HIV protease enzymes, therefore preventing HIV from multiplying.