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What is the role of Teneligliptin in diabetes?
Teneligliptin Uses: Teneligliptin is a type 2 diabetes drug that is used to treat the disease. This ensures that the medication helps in the monitoring and management of blood glucose levels, allowing them to stay within a normal range.
What is the mode of action of Teneligliptin?
Teneligliptin inhibits the action of DPP-4 enzymes and slows down the rapid degradation of incretins. It also increases insulin synthesis by the pancreas and decreases glucagon levels which are a counter-hormone of insulin, thereby further decreasing blood sugar levels.
Which is better glimepiride or Teneligliptin?
Conclusion: Teneligliptin as add-on to metformin offers low intraday glycemic variability, allowing more predictable glycemic control as compared to glimepiride and emerges as a safe, tolerable and effective treatment in patients with T2DM on more stringent criteria of glycemic variability.
How long does teneligliptin take to work?
Teneligliptin has been systematically evaluated in T2DM as monotherapy with diet and exercise and in combination with metformin, glimepiride, pioglitazone, and insulin in short-term (12 weeks) and long-term (52 weeks) studies. These studies have reported a reduction in HbA1c of 0.8\%–0.9\% within 12 weeks of therapy.
Is teneligliptin better than vildagliptin?
The study concluded that in diabetic patients with ESRD, teneligliptin significantly improved glycemic control and was well tolerated. Teneligliptin appeared to be more potent than voglibose or vildagliptin based on its glucose-lowering effects.
Which is better linagliptin or teneligliptin?
Multiple logistic analysis indicated higher baseline HbA1c was the strongest predictor of teneligliptin switching response. Conclusion: Switching from linagliptin to teneligliptin helps maintain kidney function and reduce blood glucose safely in older patients with T2D.
Which one is better teneligliptin or vildagliptin?
Can Teneligliptin and glimepiride taken together?
Therefore, teneligliptin was generally well tolerated when used in combination with glimepiride. Conclusions: The addition of teneligliptin was effective and generally well tolerated in Japanese patients with T2DM inadequately controlled with glimepiride monotherapy.
How safe is teneligliptin?
More importantly, teneligliptin is effective and safe for patients with T2DM with renal impairment, or even end-stage renal disease, without dose adjustments (Abubaker et al., 2017). Teneligliptin was synthesized in Japan and is available in Japan, Argentina, Korea and India.
What is the benefit of teneligliptin over sulfonylurea?
Conclusion: Among T2DM patients, teneligliptin therapy was not associated with an increased risk of CV events including HHF, but was associated with a lower risk of hypoglycemia compared to sulfonylurea therapy.