Sage-Tips

What does all comers mean in a clinical trial?

In an all-comers design, all patients meeting the eligibility criteria, which does not include a specific status on the biomarker in question, are entered [5].

What is a biomarker in a clinical trial?

A biomarker refers to a quantifiable biological parameter that is measured and evaluated as an indicator of normal biological, pathogenic, or pharmacologic responses to a therapeutic intervention, as defined by the National Institutes of Health.

What does all comer mean?

Definition of all-comers : not restricted to a particular group or category of participants : open At an all-comers track meet he entered the 1,500 meters in his school shorts and no shoes.—

What is the difference between marker and biomarker?

As nouns the difference between biomarker and marker is that biomarker is (medicine) a substance used as an indicator of a biological state, most commonly disease while marker is an object used to mark a location.

What kind of people participate in clinical trials?

People who participate in clinical trials do so freely and of their own will. They are volunteers. In many studies, the volunteers will have a common health condition, such as kidney disease, high blood pressure, or diabetes.

What is it like being in a clinical trial?

If you take part in a clinical trial, you may get tests or treatments in a hospital, clinic, or doctor’s office. Participants in a clinical trial are often treated in the same way as other patients who aren’t in a clinical trial, but are more carefully monitored and may have more tests done.

What does “all comers” mean in a clinical trial?

In the context of a clinical trial, “all comers” means “open to (more or less) anyone who has the condition being studied”. It applies to any trial in any disease, though it is definitely used more in the cancer world.

What does all-comers mean in a biopsy?

All-comers: All patients meeting the eligibility criteria, which does not include a specific status on the biomarker in question, are entered. The ability to provide adequate tissue may be an eligibility criterion for these designs, but not the specific biomarker result or the status of a biomarker characteristic.

What is a clicl clinical trial?

Clinical trials are research studies that involve people. Through clinical trials, doctors find new ways to improve treatments and the quality of life for people with disease. Researchers design cancer clinical trials to test new ways to: Treat cancer. Find and diagnose cancer.

What is a cancer clinical trial?

Manage symptoms of cancer and side effects from its treatment Clinical trials are the final step in a long process that begins with research in a lab. Before any new treatment is used with people in clinical trials, researchers work for many years to understand its effects on cancer cells in the lab and in animals.