Sage-Tips

Is HUS and TTP the same?

Haemolytic‐uraemic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP) are two clinically similar disorders characterized by severe microangiopathic haemolytic anaemia and thrombocytopenia.

How does Atypical HUS differ from TTP?

TTP is characteristically diagnosed when neurological features predominate, although HUS is suspected when renal failure predominates. Because of these overlapping and changing presentations, some investigators viewed TTP and HUS as one disease with a spectrum of organ involvement.

What is HUS and TTP?

Thrombotic thrombocytopenic purpura (TTP) and hemolytic uremic syndrome (HUS) are multisystemic disorders that are characterized by thrombocytopenia, microangiopathic hemolytic anemia, and ischemic manifestations, resulting from platelet agglutination in the arterial microvasculature.

How HUS is different from TTP?

HUS and TTP are characterized by the triad of microangiopathic anemia with red blood cell fragmentation, thrombocytopenia and AKI. TTP has the same three features plus the presence of fever and neurological symptoms, creating a pentad.

How is TTP different from DIC?

Thrombotic thrombocytopenic purpura (TTP) – hemolytic uremic syndrome (HUS) is a thrombotic microangiopathy superficially like DIC, but distinctly different; in contrast to DIC, the mechanism of thrombosis is not via the tissue factor (TF)/factor VIIa pathway. Results of blood coagulation assays in TTP-HUS are normal.

What causes HUS and TTP?

Although multiple triggers, such as infection, drugs, cancer, chemotherapy, bone marrow transplantation, and pregnancy, are recognized, knowledge of the pathogenesis of TTP and HUS in relationship to these disorders remains incompletely understood and continues to evolve.

What is TTP syndrome?

Thrombotic thrombocytopenic purpura (TTP) is a blood disorder in which platelet clumps form in small blood vessels. This leads to a low platelet count (thrombocytopenia).

How is TTP diagnosed?

Coombs Test This blood test is used to find out whether TTP is the cause of hemolytic anemia. For this test, a sample of blood is drawn from a vein, usually in your arm. In TTP, hemolytic anemia occurs because red blood cells are broken into pieces as they try to squeeze around blood clots.

How is HUS related to TTP?

Hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP) are two rare clinical entities. They share a common underlying pathological process termed thrombotic microangiopathy (TMA), characterized by endothelial cell injury, intravascular platelet-fibrin thrombi, and vascular damage.

Does HUS cause TTP?

Clinical studies verify that episodes of STEC-HUS can be associated with significant neurological manifestations and TTP can be triggered by gastrointestinal illnesses, suggesting overlap between these two illnesses.

What is the difference between DIC and thrombocytopenia?

Thrombocytopenia is present in both DIC and immune thrombocytopenia (ITP). However, ITP is distinct from DIC in terms of its pathophysiologic mechanism and does not involve coagulation activation or microangiopathic hemolytic anemia.

What is the difference between Haemolytic-uraemic syndrome (HUS) and TTP?

Haemolytic‐uraemic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP) are two clinically similar disorders characterized by severe microangiopathic haemolytic anaemia and thrombocytopenia. HUS is characterized by thrombocytopenia, anaemia and renal insufficiency, whereas the pentad of signs and symptoms including thrombocytopenia,

What is the pathophysiology of hemolytic uremic syndrome (HUS)?

I. INTRODUCTION. Hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP) are two rare clinical entities. They share a common underlying pathological process termed thrombotic microangiopathy (TMA), characterized by endothelial cell injury, intravascular platelet-fibrin thrombi, and vascular damage.

What are the thrombotic microangiopathies of hemolytic uremic syndrome?

The thrombotic microangiopathies include both hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP). Although debate exists as to whether these are separate entities or a spectrum of disease, both result in the clinical picture of thrombocytopenia, hemolytic anemia, and varyi …

What is the pathophysiology of thrombocytopenic purpura (HUS)?

Etiology of HUS includes diarrheal infection due to Shiga toxin-producing bacteria, complement deficiency, pneumococcal infection, and cobalamin deficiency. In disease ascribed to TTP, the main etiologic factor is deficiency of an enzyme known as a disintegrin-like and metalloprotease with thrombospondin type 1 repeats, number 13 (ADAMTS-13).