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Can low B12 cause high MPV?
A possible linkage between vitamin B12 deficiency and MPV may explain our results reporting a significant increase in MPV in post treatment period. Erythrocytes are tend to be greater in size in vitamin B12 deficiency, and similarly, it is expected that platelets should be greater in size too.
Can B12 cause high MPV?
We determined that MPV levels are increased in patients with vitamin B12 deficiency compared to healthy individuals. In a study, MPV was found to be lower in patients with vitamin B12 deficiency than in the patients without vitamin B12 deficiency as a result of production of smaller platelets [23,24].
Can vitamin D deficiency cause elevated platelets?
Background and aims: Vitamin D deficiency and increased platelet indices are associated with increased rate or risk of several diseases such as cardiovascular disease and metabolic syndrome, respectively.
Can vitamin D affect platelet count?
According to the results of this study, lower vitamin D levels will cause higher platelet counts in people with normal calcium and magnesium levels.
Why would B12 be elevated?
The most common cause of high B12 in the blood is due to recent ingestion or injection of supplemental vitamin B12. We don’t worry about overdosing on B12 supplements because excess can be excreted in your urine. It could also be possibly from your diet if high in animal products such as meat, eggs, and shellfish.
What is MPV in a blood test result?
MPV stands for mean platelet volume. Platelets are small blood cells that are essential for blood clotting, the process that helps you stop bleeding after an injury. An MPV blood test measures the average size of your platelets. The test can help diagnose bleeding disorders and diseases of the bone marrow.
Can vitamin D affect MPV?
We observed that a low vitamin D level was correlated with a high MPV. Vitamin D deficiency increases the release of proinflammatory cytokines such as IL-6 and TNF-α [16] that may lead to a high MPV. Consequently, a high MPV increases cardiac disease risk.
What does slightly elevated MPV mean?
High MPV meaning. A high MPV means that your platelets are larger than average. This is sometimes a sign that you’re producing too many platelets. Platelets are produced in the bone marrow and released into the bloodstream. Larger platelets are usually young and more recently released from the bone marrow.
What causes an increase in MPV?
Depending on your platelet count and other blood measurements, an increased MPV result can indicate: Thrombocytopenia, a condition in which your blood has a lower than normal number of platelets. Myeloproliferative disease, a type of blood cancer. Preeclampsia, a complication in pregnancy that causes high blood …
Is the MCV a useful diagnostic test for vitamin B12 deficiency?
Use of the MCV as a test for the detection or exclusion of B12 deficiency is only justified if the diagnostic accuracy is sufficiently high. However, the sensitivity and specificity are not well known. We performed a systematic review of the diagnostic value of an elevated MCV for B12 deficiency in both anaemic and non-anaemic patients.
What is hypercobalaminemia (high serum B12 levels)?
Hypercobalaminemia (high serum vitamin B12 levels) is a frequent and underestimated anomaly. Clinically, it can be paradoxically accompanied by signs of deficiency, reflecting a functional deficiency linked to qualitative abnormalities, which are related to defects in tissue uptake and action of vitamin B12.
Is there a link between vitamin D and B12 deficiency?
While medical science has yet to show that vitamin D and B12 are linked in the sense that one can trigger the other, the research indicates that there is often a common denominator responsible for both deficiencies.
How much vitamin D and B12 should you take a day?
The standard adult dosage of vitamin B12 is 2.4 mcg per day and 1,000-2,000IU for vitamin D. Those who get little to no sun exposure might need to boost their levels to 5,000IU per day. After several weeks of supplementation, you might need to undergo blood work to assess if your levels have reached a healthy range.