Table of Contents
What is the function of C-MYC?
The c-Myc gene serves as a “master regulator” of cellular metabolism and proliferation. Since it is activated by a large number of oncogenic pathways and, in turn, stimulates many of the metabolic changes that result in malignant transformation, it is truly “both the chicken and the egg”.
What does C-myc gene mean?
The Myc family was first established after discovery of homology between an oncogene carried by the Avian virus, Myelocytomatosis (v-myc; P10395) and a human gene over-expressed in various cancers, cellular Myc (c-Myc).
What cancer does C-MYC cause?
MYC is documented to be involved broadly in many cancers, in which its expression is estimated to be elevated or deregulated in up to 70\% of human cancers. High levels of MYC expression have been linked to aggressive human prostate cancer and triple negative breast cancer (Gurel et al., 2008; Palaskas et al., 2011).
Is C-MYC the same as Myc?
The MYC oncogene family consists of three members, C-MYC, MYCN, and MYCL, which encode c-Myc, N-Myc, and L-Myc, respectively. The Myc oncoproteins belong to a family of so-called “super-transcription factors” that potentially regulate the transcription of at least 15\% of the entire genome.
Is c-Myc a proto-oncogene?
The proto-oncogene c-myc has been shown to play a pivotal role in cell cycle regulation, metabolism, apoptosis, differentiation, cell adhesion, and tumorigenesis, and participates in regulating hematopoietic homeostasis. It is a transcription regulator that is part of an extensive network of interacting factors.
When was c-Myc discovered?
The c-Myc transactivation domain was identified through studies with GAL4 fusion proteins (Kato et al., 1990). The first 143 amino acids, which comprises of Myc Box I (residues 45–63) and Box II (residues 128–143), are sufficient for gene activation.
When was C-MYC discovered?
Is Myc a tumor suppressor gene?
The tumor suppressor p53 negatively regulates a number of genes, including the proto-oncogene c-Myc, in addition to activating many other genes. One mechanism of the p53-mediated c-Myc repression may involve transcriptional regulation.
What is c-myc translocation?
c-MYC is the prototype for oncogene activation by chromosomal translocation. In contrast to the tightly regulated expression of c-myc in normal cells, c-myc is frequently deregulated in human cancers.
What is c-myc promoter?
The transcription factor c-Myc is a key regulator of cell proliferation, cell growth, differentiation, and apoptosis. Deregulated c-myc expression possesses a high transformation potential and the proto-oncogene c-myc represents a promising target in anticancer therapy.
What is c-Myc promoter?
What does Myc stand for?
MYC is a family of regulator genes and proto-oncogenes that consist of three human genes: c-MYC, l-MYC, and n-MYC. The official MYC medical term is MYC proto-oncogene, bHLH transcription factor, and MYC gene abbreviation is simply MYC.
What is the c-myc gene?
MYC genes are often associated with cancer and the growth of cancerous tumors, most specifically the c-MYC gene, which is also commonly referred to as MYCC. In fact, mutated c-MYC genes are overexpressed in at least 40\% of tumors and the majority of human cancers 1.
How is c-Myc regulated?
Due to its involvement in a variety of cellular functions, it is critical for c-Myc to be tightly regulated. Transcription of c-Myc is controlled by developmental or mitogenic signals.
What is the half life of c-Myc?
The short half-life of c-Myc in proliferating cells (approximately 30 minutes) make this a particularly effective mechanism of gene regulation. c-Myc has been shown to undergo ubiquitylation and degradation by the proteasome. This includes phosphorylation-dependent degradation of c-Myc.