Sage-Tips

Does liver transplant need HLA matching?

However, in liver transplantation, a more specific investigation of HLA typing may be necessary, because in some indications HLA antigens play a role in the nature of the disease. Therefore, recurrence of autoimmune disease may be more severe in patients sharing HLA antigens.

Is HLA matching required for lung transplant?

Histocompatibility in terms of HLA matching is only considered in kidney allocation, but it does not play a role in nonrenal transplantation. So far, HLA typing and antibody screening is not required for each patient according the current national guidelines and ET recommendations for lung transplantation.

Does heart transplant need HLA matching?

HLA matching is currently not a factor in heart transplant donor allocation. Authors of previous reports have argued that HLA matching should be considered in cardiac donor allocation because of improved outcomes. HLA matching has been used in organ allocation in kidney transplantation.

Do liver transplants need to match?

Donors must have a compatible blood type and liver anatomy that is suitable for donation. Potential liver donors must not have any serious medical conditions, such as liver disease, diabetes, heart disease or cancer.

Which antigens must be matched optimally between donors and recipients of solid organ transplants?

Matching for HLA class II antigen (DR antigens) is considered even more important [2] and thus donor recipient pairs that match for six antigens (two of locus A, two locus B and two HLA-DR) have been found to have much better long term graft survival than the zero-antigen matched group or those with one, two or more …

What makes a match for liver transplant?

Your Blood Type Is a Good Match If you have Type O blood, you are a “universal donor” and can donate to anyone (although Type O liver recipients can only get organs from people who are also Type O). If you are Type A, you can donate to those who are also Type A as well as Type AB.

Why is HLA matching important?

HLA matching is important for transplant HLA matching promotes the growth and development of new healthy blood cells (called engraftment) and reduces the risk of a post-transplant complication called graft-versus-host (GVHD) disease.

What is the impact of HLA matching on solid organ and bone marrow?

The influence of HLA matching on solid organ and bone marrow transplantation is also described. HLA matching has had the greatest clinical impact in kidney and bone marrow transplantation, where efforts are made to match at the HLA-A, -B, and -DR loci.

Does matchmaking matter in heart and lung transplantation?

In heart and lung transplantation, although studies have shown it would be an advantage to match especially at the DR locus, practical considerations (ischemic times, availability of donors, clinical need of recipients) make this less of a consideration.

Does HLA matching influence the success rate of atopic corneal grafts?

Corneal grafts are not usually influenced by HLA matching, unless being transplanted into a vascularized (or inflamed) bed. Publication types Review MeSH terms

What are the different methods of HLA typing?

Three methods for HLA typing are described in this chapter, including serological methods and the molecular techniques of sequence-specific priming (SSP) and sequence-specific oligonucleotide probing (SSOP). The influence of HLA matching on solid organ and bone marrow transplantation is also described.