Sage-Tips

What is the formula for calculating GFR?

Race	Sex	Equation (age in years for ≥ 18)
White or other	Female	GFR = 144 × (Scr/61.9)-0.329 × (0.993)Age
White or other	Female	GFR = 144 × (Scr/61.9)-1.209 × (0.993)Age
White or other	Male	GFR = 141 × (Scr/79.6)-0.411 × (0.993)Age
White or other	Male	GFR = 141 × (Scr/79.6)-1.209 × (0.993)Age

How does creatinine clearance related to GFR?

Creatinine clearance ( CrCl ) is an estimate of Glomerular Filtration Rate ( GFR ); however, CrCl is slightly higher than true GFR because creatinine is secreted by the proximal tubule (in addition to being filtered by the glomerulus). The additional proximal tubule secretion falsely elevates the CrCl estimate of GFR .

How do I calculate my Usmle GFR?

GFR = [UrineX (mg/mL)] * urine flow (mL/min)/ [PlasmaX (mg/mL)], where X is a substance that is completely excreted.

How do you read GFR results?

A GFR of 60 or higher is in the normal range. A GFR below 60 may mean kidney disease. A GFR of 15 or lower may mean kidney failure.

How do you calculate GFR per day?

The abbreviated MDRD equation has been developed, to facilitate calculation of the GFR:GFR (mL/min per 1.73 m2;1.21) = 186.3 x Serum Creatinine (exp[-1.154]) x Age (exp[-0.203]) x (0.742 if female) x (1.21 if african american)To use this formula to gain an idea of your GFR, you should input your age, gender, race and …

How is kidney clearance calculated?

Ask yourself, “What would the renal clearance be if the ClRen depended only on glomerular filtration?” ClRen = GFR * fu = (125 ml/min) * (0.5) = 62.5 ml/min. The actual value (ClRen = 10 ml/min) is lower than this calculated value based only on filtration, i.e. less drug is being removed from the body than we expected.

What is clearance in the kidney?

Renal clearance (ClR) is a measure of kidney transport in units of volume of plasma per unit time. The volume of plasma measured is that volume for which a given substance (e.g., urea or drugs) is completely removed per minute.

How do you calculate GFR manually?

eGFR can also be calculated by using the eGFR calculator below.

1. Serum Creatinine * µmol/L.
2. Age *
3. eGFR= mL/min/1.73m 2

What is normal GFR?

What is total clearance and renal clearance ratio?

Clearance is the parameter that determines total systemic exposure to drug, which is simply the ratio of dose/clearance. Total body clearance is the sum of all processes by which drugs are removed from the body or inactivated, primarily renal excretion and metabolism.

What is the formula for calculating creatinine clearance?

Creatinine Clearance = [[140 – age(yr)]*weight(kg)]/[72*serum Cr(mg/dL)] (multiply by 0.85 for women). The results you receive from this tool are for informational purposes only and should not be the basis of your medical decision making.

How to calculate GFR manually?

Calculator above uses the abbreviated MDRD equation: Estimated GFR (ml/min/1.73m2) = 186 x (Creat / 88.4)-1.154 x (Age)-0.203 x (0.742 if female) x (1.210 if black)

What is the difference between creatinine clearance and GFR?

The key difference between Creatinine Clearance and GFR relies on the type of test that helps analyze each measurement. Creatinine clearance analysis takes place via urine test whereas GFR analysis takes place via a blood test. Renal health depends on the efficiency and accuracy of kidney functioning.

How to figure out GFR?

The best method for directly determining the GFR is a procedure called an “inulin clearance.”. It involves introducing a fluid containing the marker molecule inulin (NOT insulin) into your veins (IV – intravenous infusion) and then collecting timed urines over a period of hours.