Sage-Tips

What is the first-line of treatment for ITP?

The standard initial treatment for ITP is oral corticosteroids to increase platelet counts. Intravenous immunoglobulin or anti-D immunoglobulin can also increase platelet counts and are particularly useful for stimulating rapid platelet increases before planned procedures.

How do you treat TTP?

Plasma exchange (also called plasmapheresis) is used to treat acquired TTP. This is a lifesaving procedure. It removes antibodies (proteins) from the blood that damage your ADAMTS13 enzyme. Plasma exchange also replaces the ADAMTS13 enzyme.

What is the first-line management of idiopathic thrombocytopenic purpura ITP in adults?

Corticosteroids remain the mainstay of initial management of ITP. Intravenous immunoglobulin (IVIG) and anti-D immune globulin (in patients who have an Rh-positive blood type) have also been recommended as first-line treatment options.

What causes thrombocytopenic purpura?

What causes idiopathic thrombocytopenic purpura? In ITP, the immune system is stimulated to attack your body’s own platelets. Most often this is a result of antibody production against platelets. In a small number of cases, a type of white blood cell called T-cells will directly attack platelets.

Which drug is useful in management of idiopathic thrombocytopenic purpura refractor to prednisone?

Cyclosporin A for the treatment of patients with chronic idiopathic thrombocytopenic purpura refractory to corticosteroids or splenectomy. Br J Haematol. 2001 Jul;114(1):121-5. doi: 10.1046/j.

What medication increases platelets?

Drugs that boost platelet production. Medications such as romiplostim (Nplate) and eltrombopag (Promacta) help your bone marrow produce more platelets. These types of drugs can increase your risk of blood clots.

What is thrombotic thrombocytopenic purpura?

Thrombotic thrombocytopenic purpura is a rare disorder that causes blood clots (thrombi) to form in small blood vessels throughout the body. These clots can cause serious medical problems if they block vessels and restrict blood flow to organs such as the brain, kidneys, and heart.

Which drug is useful in management of idiopathic thrombocytopenic purpura refractory to prednisone?

Presently, rituximab seems to be the most promising drug for treatment of refractory ITP.

How can thrombocytopenia be prevented?

Prevention

1. Avoid medicines that thin blood and increase bleeding risk, such as aspirin, naprosyn and ibuprofen.
2. Take care with contact sports and activities that can cause injuries, bruising and bleeding.
3. Minimize contact with toxic chemicals.
4. Take extra care when shaving, brushing your teeth and blowing your nose.

How do you treat ITP in dogs?

The mainstay of treatment for ITP is immunosuppressive corticosteroid therapy, usually given as prednisone starting at 2 mg/kg/day (or 30 mg/m2 for larger-breed dogs). This dose is gradually reduced once the platelet count has returned to normal, typically with dose reductions of 25\% every two to four weeks.

What medications can cause purpura?

Other drugs associated with drug purpura include the following:

• Antibiotics (eg, cephalosporins, rifampicin)
• Gold salts.
• Analgesics.
• Neuroleptics.
• Diuretics.
• Antihypertensives.

Is ITP considered cancer?

Cite M. Khasraw, S. Baron-Hay; Immune thrombocytopenic purpura (ITP) and breast cancer. Although both breast cancer and immune thrombocytopenic purpura (ITP) are common conditions, the simultaneous coexistence of these two diseases is rare.

How do I treat ITP blood?

When you do need treatment, the goal is to get your platelet count to a level that’s high enough to prevent serious bleeding in the gut or brain. Your doctor will likely suggest these treatments for ITP first: Corticosteroids. Dexamethasone or prednisone is typically prescribed to raise your platelet count.