Sage-Tips

What is TB notification?

Associated terms. Morbidity. Definition Number of new and relapse TB cases notified in a given year, per 100 000 population. The term “notification” means that TB is diagnosed in a patient and is reported within the national surveillance system, and then on to WHO.

What is the difference between IGRA and QuantiFERON?

QFT is an interferon-gamma (IFN-γ) release assay, commonly known as an IGRA, and is a modern alternative to the tuberculin skin test (TST, PPD or Mantoux). Unlike the TST, QFT is a controlled laboratory test that requires only one patient visit and is unaffected by previous Bacille Calmette-Guerin (BCG) vaccination.

What is a QuantiFERON TB Gold Plus test?

QuantiFERON-TB Gold Plus (QFT-Plus) is a simple blood test that aids in the detection of Mycobacterium tuberculosis, the bacteria which causes tuberculosis (TB). You can improve your TB testing by switching from the TB skin test (Tuberculin Skin Test, also known as the Mantoux or PPD test) to QFT-Plus (1):

What does a positive TB screen mean?

A “positive” TB blood test result means you probably have TB germs in your body. Most people with a positive TB blood test have latent TB infection. To be sure, your doctor will examine you and do a chest x-ray. You may need other tests to see if you have latent TB infection or active TB disease.

Where do I notify a TB case?

Tuberculosis (TB) notification is defined as the process of reporting diagnosed TB cases to relevant health authorities, which in turn report them to the World Health Organization (WHO) through National TB Programmes (NTPs) or their equivalent.

Which TB cases should be notified?

Notified cases of tuberculosis

• New cases: extrapulmonary.
• Treatment history unknown.
• New cases: Pulmonary, smear-positive.
• Relapse cases (pre-2013 definition)
• Relapse cases: extrapulmonary.
• New cases: Pulmonary, smear-negative/unknown/not done and other new cases.
• Relapse cases: Pulmonary, clinically diagnosed.

What is TB1 and TB2?

TB1 is designed to target cell mediated responses from CD4 T-cells, while TB2 contains newly designed peptides designed to also stimulate CD8 T-cells.

Which is better QuantiFERON or T-spot?

Although current data suggest that the T-SPOT. TB test is superior to the QuantiFERON-TB Gold test in immunosuppressed patients, the number of studies comparing the two tests is limited.

How do you read QuantiFERON results?

How are QFT-Plus results interpreted?

1. Positive – suggests that TB infection is likely.
2. Negative – suggests that TB infection is unlikely.
3. Indeterminate – suggests the need for further investigations or repeat testing.

How effective is QuantiFERON test?

Highly accurate and reproducible. >97\% specificity and >94\% sensitivity. Convenient and objective lab-based testing.

How is TB diagnosed?

There are two kinds of tests that are used to detect TB bacteria in the body: the TB skin test (TST) and TB blood tests. A positive TB skin test or TB blood test only tells that a person has been infected with TB bacteria.

How do you read a TB test?

In a healthy person whose immune system is normal, induration greater than or equal to 15 mm is considered a positive skin test. If blisters are present (vesiculation), the test is also considered positive. In some groups of people, the test is considered positive if induration less than 15 mm is present.

How to create a tree in TB-profiler?

A. At the moment TB-Profiler does not provide any functionality to actually create the tree. The config files for itol are generated, however the tree must be created with other software. It is planned for future releases, however it might take some time to be fully developed.

What database does tbtbprofiler ship with?

TBProfiler ships with a default database. The development of the mutation library is hosted on the tbdb repository. Please visity this repo if you would like to get involved in the database or would like to modify and create your own.

What config files are produced by TB-profile collate?

Several files are produced by the tb-profile collate function. Among these are several config files that can be used with iTOL to annotate phylogenetic trees. A small tree and config files have been placed in the example_data directory.

How do I access the profiler in tensorboard?

Access the Profiler from the Profile tab in TensorBoard, which appears only after you have captured some model data. Note: The Profiler requires internet access to load the Google Chart libraries . Some charts and tables may be missing if you run TensorBoard entirely offline on your local machine, behind a corporate firewall, or in a data center.