Table of Contents
How do you decide which embryo to transfer?
Knowing which embryo to transfer with the help of genetic testing
- Biopsy. A few days after fertilization, an embryologist will biopsy the cells that will become the placenta.
- Vitrification.
- Testing.
- Preimplantation genetic testing for monogenetic disease (PGT-M).
- Results.
Is 4AA or 5AA better?
What is the ‘perfect’ blastocyst grading score? A morphologically “perfect” day 5 embryo transfer would be a 4AA; good expansion and excellent inner cell mass and trophectoderm. When a blastocyst scores 5AA on day five the blastocyst is starting to “hatch” with normal appearing inner cell mass and trophectoderm.
How many blastocysts is good for IVF?
A blastocyst is the final stage of the embryo before we cryopreserve them or transfer to a patient. Only 30-50\% of embryos growing on day 3 will reach the blastocyst stage. So from our 8 embryos that initially fertilized, about 3-4 will be viable for transfer.
Should I transfer 1 or 2 embryos after PGS?
This is the reason that ASRM guidelines recommend only transferring one embryo at a time when you use egg donation or are transferring embryos that are normal by PGS. It is much safer and more effective. Transferring two embryos at a time is essentially wasting an embryo and putting you at risk.
Is it better to transfer a hatching blastocyst?
Our study confirms that extending blastocyst culture by few hours allows better developed, top-quality hatching/hatched blastocyst for transfer which subsequently improves implantation and pregnancy/live birth rates with no added risk of multiple pregnancies compared with EBT.
What is a high quality blastocyst?
A high-quality blastocyst was defined as having a grade of at least 3BB, including 3/4/5AA, AB, BA, or BB [16, 17]. All lab operations for gametes, zygotes, and embryos were conducted by two embryologists with considerable intra- and inter-observer variability in quality control proficiencies.
Does a hatched blastocyst implant faster?
CONCLUSION: Extending culture of expanded blastocysts by a few hours to allow transfer of spontaneously hatching/hatched blastocysts gives higher implantation and pregnancy rates with no added risk of multiple gestations.
What is 3BB embryo?
Embryo Quality Good quality (≥3BB) and poor quality (<3BB) were evaluated. Good quality blasts (≥3BB) a live birth rate of 41\% was achieved. Poor quality (<3BB): 26\%.
Can a 3BB embryo implant?
Embryos graded as BB (3BB, 4BB, 5BB, 6BB) still have a good chance of success at 50\% for pregnancy and 42.3\% for live birth. While those graded BC or CB have about a third chance of implantation and 25\% chance of live birth.
Can an embryo split after IVF transfer?
The chance of a single embryo dividing and resulting in identical twins is higher after IVF than after natural conception. So it is possible to end up with identical twins from a single transferred embryo.