Can ankylosing spondylitis be cured permanently?
There is no permanent cure for ankylosing spondylitis, but symptoms can be managed effectively with appropriate treatment, physical therapy, exercise and lifestyle modifications.
Which treatment is best for HLA-B27 positive?
Conclusions: Infliximab, adalimumab, and etanercept were effective for treating and reducing the number of uveitis relapses in HLA-B27-positive AS.
Is HLA-B27 rare?
HLA-B27 is rare in the American black population whereas Eskimo populations carry it much more frequently than Western Europeans, with prevalence rates of 25\% or more. This antigen is associated with ankylosing spondylitis in virtually all racial groups studied.
What are the chances of developing spondyloarthropathy with HLA B27?
HLA-B27 is found in 88\% of patients with ankylosing spondylitis. It is inherited in a Mendelian fashion, and it is found in 50\% of first-degree relatives of those patients with spondyloarthropathies who are HLA-B27 positive. The chance that an HLA-B27 patient will develop spondyloarthritis or eye disease is 1 in 4.
What is the role of HLA-B27 testing in the diagnosis of unilateral AAU?
The role of HLA-B27 testing in patients with unilateral AAU is important in the differential diagnosis. The lack of HLA-B27 antigen in unilateral AAU may be a clue for the clinician to search for other specific uveitis entities and other systemic diseases.
What is the role of HLA-B27 in the pathogenesis of autoimmune disease?
The actual role of HLA-B27 in triggering an inflammatory response causing disease is still not precisely known. The oldest theory is that of molecular mimicry, in which an autoimmune response initially is mounted against a peptide from an infectious agent and is subsequently directed against HLA-B27 itself due to epitopic similarities.
What is the prevalence of HLA-B27 positive atrioventricular atrophy (AAU)?
Of patients with AAU, 50-60\% may be HLA-B27 positive. It is generally an acute onset nongranulomatous unilateral disease presenting as a classic triad of pain, redness, and photophobia]