Table of Contents
What does it mean if your Complement C3 is high?
Your complement levels will often rise very high just after an infection or injury. When your complement system responds to ongoing disease such as lupus, levels usually go down. You can inherit a deficiency in your complement C3. But it’s much more common to acquire a deficiency.
What is C3 in complement cascade?
Complement component C3 plays a particularly versatile role in this process by keeping the cascade alert, acting as a point of convergence of activation pathways, fueling the amplification of the complement response, exerting direct effector functions, and helping to coordinate downstream immune responses.
What do high levels of C3 and C4 mean?
It seems that elevated C3 and C4 are likely to result of increased synthesis in the liver in response to cytokines e.g. IL-1β, IL-6 or tumor necrosis factor (TNF), which are increased in active CU and are known to control synthesis of the APR proteins [9].
What is C3 in complement system?
Complement component 3, often simply called C3, is a protein of the immune system. It plays a central role in the complement system and contributes to innate immunity. In humans it is encoded on chromosome 19 by a gene called C3.
What is the normal range for C3 complement?
The normal range is 88 to 201 milligrams per deciliter (mg/dL) (0.88 to 2.01 g/L). Note: Normal value ranges may vary slightly among different laboratories.
What does high ch50 mean?
Increased levels of complement may indicate: Acute-phase immune response. Cancer. Ulcerative colitis.
What is the role of C3?
The C3 gene provides instructions for making a protein called complement component 3 (or C3). This protein plays a key role in a part of the body’s immune response known as the complement system. The C3 protein is essential for turning on (activating) the complement system.
Why is C3 low and C4 normal?
This is the result of an acquired disease. If your C3 and C4 levels are reduced, this may be a sign that you have lupus. Usually your total complement level is also slightly lower in this situation. Low C3 and C4 levels may also be a sign of alcoholic liver disease, but this is less common.
What causes elevated CH50?
If your results show higher than normal amounts or increased activity of complement proteins, it may mean you have one of the following conditions: Certain types of cancer, such as leukemia or non-Hodgkin lymphoma. Ulcerative colitis, a condition in which the lining of the large intestine and rectum become inflamed.