Table of Contents
What does HIF mean?
Abbreviations
| HIF-1 | Hypoxia-Inducible Factor |
|---|---|
| ARNT | aryl hydrocarbon receptor nuclear translocator |
| VEGF | vascular endothelial growth factor |
| FIH | factor Inhibiting HIF-1 |
| VHL | von-Hippel-Lindau |
What is an HIF stabilizer?
HIF stabilizer is an inhibitor of HIF-PHD which stimulates endogenous EPO by mimicking hypoxia with HIF-PHD inhibition [66].
What Is HIF in cancer?
Hypoxia-inducible factor 1 (HIF-1) activates the transcription of genes that are involved in crucial aspects of cancer biology, including angiogenesis, cell survival, glucose metabolism and invasion.
What is the HIF pathway?
Abstract. Hypoxia-inducible factor (HIF) is an alpha,beta-heterodimeric transcription factor that mediates cellular responses to low oxygen concentration via the transcriptional activation of specific genes involved in both tumorogenesis and angiogenesis.
What Is HIF in biology?
Hypoxia-inducible factor (HIF) is a sequence-specific DNA-binding protein that can promote or repress the transcription of a broad range of genes that are involved in maintaining biological homeostasis. Overall, the genes targeted by HIF help cells to adapt to, and thereby survive in, a stressful microenvironment.
What is the full form of Deb?
DEB Full Form
| Full Form | Category | Term |
|---|---|---|
| Debenture | Accounts and Finance | DEB |
| Debrecen | Airport Code | DEB |
| Orbital Debris | Military and Defence | DEB |
| Deadly Energy Blast | Military and Defence | DEB |
How does HIF increase performance?
The target genes of HIF-1 increase oxygen transport through mechanisms such as erythropoietin-mediated erythropoiesis and vascular endothelial growth factor-induced angiogenesis and improve tissue function during low oxygen availability through increased expression of glucose transporters and glycolytic enzymes, which …
How do HIF inhibitors work?
Hypoxia-inducible factor (HIF) prolyl hydroxylase (PH) enzyme inhibitors are a new class of agents for the treatment of anemia in CKD. These agents work by stabilizing the HIF complex and stimulating endogenous erythropoietin production even in patients with end-stage kidney disease.
Is HIF an oncogene?
Given the results presented above of the extended analysis of data in Westerlund et al., and the uniform conclusions of published reports, we see no reason to change the general view that HIF-2 has oncogenic function(s) in neuroblastoma and other tumor forms.
What is the role of HIF?
HIF is a transcription factor that plays an essential role in the cellular response to low oxygen, orchestrating a metabolic switch that allows cells to survive in this environment. In immunity, infected and inflamed tissues are often hypoxic, and HIF helps immune cells adapt.
What genes does HIF regulate?
HIF activates genes that control cellular oxygen homeostasis, including genes involved in oxygen consumption, erythrocyte production, angio- genesis, and mitochondrial metabolism. Hypoxic cells counter stress by transcriptional and post-transcriptional mechanisms, mainly regulated by HIF.
What type file is the ‘HIF’ file?
What type file is the ‘HIF’ file? 06-11-2001 11:11 PM 06-11-2001 11:11 PM them normally as System Printers. Then in the Plotter Wizard you can create a pc3 file for the driver. So 1st install the drivers as system printer and then create the pc3-file with the wizard.
What are HIF-prolyl hydroxylases?
HIF-prolyl hydroxylases (PHs) are molecules that constitute the core molecular mechanism of detecting a decrease in the partial pressure of oxygen, or hypoxia, in the cells; they can be called oxygen sensors.
What does HIF-pH stand for?
Thus, HIF-prolyl hydroxylases (HIF-PHs) constitute the core molecular mechanism of detecting a decrease in the partial pressure of oxygen, or hypoxia, in the cells; they can be called oxygen sensors [19,20].
What is hypoxia inducible factor (HIF)?
Hypoxia-inducible factor (HIF) plays an essential role in this process; it is a transcription factor that was genetically isolated while elucidating the molecular mechanism through which EPO is induced at the transcriptional level in hypoxia [11].