Table of Contents
Do statins reduce LDL particle number?
Results — Statins reduced LDL particle concentration (LDL-P) less than LDL-C (−30\% to −38\% vs. −38\% to −51\%). Reductions were greater with RSV than with ATV (P < 0.05 for LDL-P, P < 0.001 for LDL-C).
How do you reduce the number of LDL particles?
Can I reduce my amount of small, dense LDLs?
- Eat a diet very rich in soluble fiber (BYOBB) – Beans, Yams, Oats, Barley, and Berries.
- Eat fewer refined carbohydrates.
- Eat much less saturated and trans fats and cholesterol.
- Exercise regularly, and.
- Lose excess weight.
What determines LDL particle size?
Thus, the LDL apo B concentration is the plasma concentration of LDL particles. The size of an LDL particle depends on how much lipid is in the core, and the lipid content naturally determines its density. Thus, smaller LDL is denser, larger LDL is lighter, and the two qualities are largely equivalent.
What increases small dense LDL particles?
Fructose increases levels of small, dense LDL particles more than glucose does. Saturated fat increases levels of HDL cholesterol. Saturated fat increases levels of large buoyant LDL cholesterol.
What does a high LDL particle number mean?
LDL cholesterol levels should be less than 100 mg/dL. Levels of 100 to 129 mg/dL are acceptable for people with no health issues but may be of more concern for those with heart disease or heart disease risk factors. A reading of 130 to 159 mg/dL is borderline high and 160 to 189 mg/dL is high.
What causes small particle LDL?
There is a genetic pre-disposition to have small dense LDL. An atherogenic lifestyle involving minimal activity or exercise along with a typical American diet high in saturated fat is another cause. Insulin resistance or pre-diabetes is the last major cause of small dense LDL.
Is LDL and LDL C the same?
Low-density lipoprotein (LDL) is conventionally quantified in terms of the mass of cholesterol carried by these particles. LDL cholesterol (LDL-C) has been the standard measure of LDL and LDL-attributable cardiovascular disease (CVD) risk for so long that “LDL” and “LDL-C” tend to be used interchangeably.
What is the LDL particle number mean?
LDL-P is a measurement of the number of LDL particles in serum as opposed to LDL-C which is the measurement of the amount of cholesterol inside the LDL particle.
What is LDL C in blood test?
The direct low-density lipoprotein cholesterol test (direct LDL-C) measures the amount of LDL cholesterol, sometimes called “bad” cholesterol, in the blood. Elevated levels of LDL-C are associated with an increased risk of hardening of the arteries (atherosclerosis) and heart disease.
What is normal LDL particle number?
A value of less than 1,000 is considered ideal. Above 2,000 is considered very high. LDL-P is measured in nmol/L.
Does LDL-C concentration matter?
The LDL-C concentration doesn’t account for the possibility of a high number of TG-rich LDLs (of any size) or small, dense LDL (sdLDL) particles that may be associated with a “normal” LDL-C level. 1,2 Because of this, there is good reason to look beyond just LDL-C and non-HDL-C levels and focus goals of therapy on other lipid parameters. 2-4
What is the normal range for LDL C?
LDL-C levels: LDL-C levels are the best gauge of risk of heart attack and stroke. Less than 100 mg/dL is optimal, while 100-129 mg/dL is near optimal. 130-150 mg/dL is borderline high, 160-189 mg/dL is high, and 190 mg/dL or above is extremely high.
Is there discordance between LDL-C and LDL-P?
If LDL-C is high and LDL-P is low, there is discordance. If LDL-C is low and LDL-P is high, there is discordance. If both are low or both high, there is no discordance. Studies have indicated that if there is discordance between LDL-C and LDL-P, cardiovascular disease risk tracks more closely with LDL-P than LDL-C.
How do I know if I have large LDL cholesterol particles?
All you have to do is determine your ratio of triglycerides to HDL cholesterol, which would be found as part of the results of your last cholesterol screening. If you ratio is less than 2, you have predominantly large, fluffy LDL particles that are not going to do you much harm.