Sage-Tips

Can you have ankylosing spondylitis without HLA-B27 gene?

Blood can be tested for the HLA-B27 gene. But many people who have that gene don’t have ankylosing spondylitis and people can have the disease without having the gene.

Do all people with ankylosing spondylitis have the HLA-B27 gene?

For example, 80-90\% of patients with ankylosing spondylitis have HLA-B27. Expressed as a relative risk, an HLA-B27 positive individual is approximately 87 times more susceptible to developing ankylosing spondylitis compared to the general population.

What percentage of ankylosing spondylitis is HLA-B27 positive?

HLA-B27 is found in 88\% of patients with ankylosing spondylitis. The chance that an HLA-B27 patient will develop spondyloarthritis or eye disease is 1 in 4.

What are the chances I have ankylosing spondylitis?

If you have AS and tests show you carry the HLA-B27 gene then there is a 1 in 2 chance that you could pass on the gene to any children you have. It is estimated that between 5 to 20\% of children with this gene will then go on to develop AS.

Can ankylosing spondylitis be seronegative?

Seronegative spondyloarthropathies are a family of joint disorders that classically include ankylosing spondylitis (AS), psoriatic arthritis (PsA), inflammatory bowel disease (IBD) associated arthritis, reactive arthritis (formerly Reiter syndrome; ReA), and undifferentiated SpA.

What if HLA-B27 is negative?

A negative result means you don’t have HLA-B27 in your blood. A positive result means HLA-B27 was found in your blood. You may have a higher-than-average risk of certain autoimmune diseases, such as ankylosing spondylitis and reactive arthritis.

What does HLA-B27 negative mean?

Which is worse seropositive or seronegative RA?

For example, a Dutch study found that seronegative RA patients had significantly greater disease activity and worse functional ability than seropositive patients; on the other hand, seropositive patients had greater joint damage.

What does it mean if you are HLA B27 positive?

A positive HLA-B27 test means that the person tested is at increased risk of developing certain autoimmune diseases.

What is HLA B 27?

HLA-B27 is a genetic marker. In people with inflammatory arthritis of the spine and joints (not osteoarthritis), a positive HLA-B27 test is associated with the presence of one of a group of diseases called seronegative spondyloarthropathies.

Is HLA B27 genetic?

Response from Dr. Holodniy. Human Leukocyte Antigen B27 (HLA-B27) is a genetic marker of AS. There are many people with B27 that do not get AS. About 5\% with B27 get AS. Most people with AS have B27. It is thought that HLA-B27 interacts with other proteins in the body, affecting the body’s normal immune response.

What is the CPT code for HLA B27?

Lab Order Codes: B27. Synonyms: HLA-B27, blood. CPT Codes: 86812 –HLA typing; A, B, or C, single antigen. Test Includes: HLA-B27 interpretive report will be provided.