Table of Contents
Are ICR mice outbred?
ICR mice are one the most commonly available outbred population because they have good reproductive performance, are inexpensive, robust, and grow rapidly [5,6].
What are mouse strains?
C57BL/6 and BALB/c are the main mouse strains. Sprague-Dawley and Wistar are the main rat strains. The Jackson Laboratory, Charles River Laboratories, Taconic Biosciences, and Harlan Laboratories are the main suppliers. Major research applications are in immunology, oncology, physiology, pathology, and neuroscience.
How many mouse strains are there?
Over 400 standardized, inbred strains have been developed. Most laboratory mice are hybrids of different subspecies, most commonly of Mus musculus domesticus and Mus musculus musculus.
What does CD1 mice stand for?
CD1 (cluster of differentiation 1) is a family of glycoproteins expressed on the surface of various human antigen-presenting cells.
Why are SCID mice used?
What are SCID mouse models typically used for? SCID models are typically used in biology studies of the immune system. SCID mouse models are also used for tumor growth studies and studies of normal and abnormal lymphocyte development and function.
What is C3H?
C3H/HeJ mice, commonly called C3H, are used as a general purpose strain in a wide variety of research areas including cancer, infectious disease, sensorineural, and cardiovascular biology research.
What is transgenic mouse strain?
Transgenic mice are mouse models that have had their genomes altered for the purpose of studying gene functions.
What does white mouse mean?
albino house mouse
: an albino house mouse.
What is CD mouse?
CD-1 IGS mice are outbred mice derived from a group of outbred Swiss mice developed at the Anti-Cancer Center in Lausanne, Switzerland. They were imported to the US in 1926 and to Charles River in 1959. Inbred mice are almost genetically identical, which allows for easier interpretation of experiments.
Are CD1 mice immunocompetent?
CD-1® Nude Mouse Details Developed from the transfer of the nude gene from Crl:NU-Foxn1nu to a CD-1® mouse through a series of crosses and backcrosses beginning in 1979 at Charles River Laboratories, Wilmington, MA. The animal lacks a thymus, is unable to produce T-cells, and is therefore immunodeficient.
What is the full form of SCID?
Severe combined immunodeficiency (SCID) is a group of rare disorders caused by mutations in different genes involved in the development and function of infection-fighting immune cells. Infants with SCID appear healthy at birth but are highly susceptible to severe infections.
Do SCID mice have monocytes?
Some SCID mice are able to produce monocytes, granulocytes, and red blood cells from the hematopoietic stem cells (HSC) present in their bone marrow.