Table of Contents
What happens if LDL is oxidized?
“Oxidized LDL moves rapidly into arterial walls and engorges them with cholesterol,” Meyer said. “Cholesterol ultimately converts into plaque, blocking the arteries or, in a worst case scenario, rupturing and sending clots into the bloodstream, causing heart attacks and/or strokes.”
What is the effect of oxidised LDL in the arterial wall?
Oxidized LDL is highly atherogenic as it stimulates macrophage cholesterol accumulation and foam cell formation, it is cytotoxic to cells of the arterial wall and it stimulates inflammatory and thrombotic processes.
Where does oxidation of LDL occur?
The oxidation process modifies a lysine amino acid on the apolipoprotein B. Oxidation of LDL can occur in any of the cells within the artery, including the endothelial cells, macrophages, smooth muscle cells and T lymphocytes.
What happens when LDL is removed from circulation?
LDL clearance involves binding to its receptor, LDLR, which enables the internalization of the LDL particle and drives its degradation in lysosomes. Once the LDL particle is degraded, the free receptor recycles to the plasma membrane, and captures new LDL particles.
How do you get rid of oxidized LDL cholesterol?
There are things that you can do to stop the damage from oxidized LDL.
- Focus on eating healthy fats.
- Eat saturated fats in moderation.
- Include plenty of fresh fruits and vegetables in your diet.
- Pay attention to nutrition labels, and stay away from hydrogenated or partially hydrogenated foods.
What causes LDL oxidation?
The oxidation of LDL is thought to occur when LDL cholesterol particles in your body react with free radicals; unstable molecules that are produced as a result of normal metabolism, a disease, or exposure to toxins. LDL cholesterol molecules are not all the same size, and some are larger than others.
Why does LDL get oxidized?
How do you get rid of oxidized LDL?
What is a consequence of the oxidation of low density lipoproteins LDLs?
High LDL cholesterol levels can place you at risk for developing cardiovascular disease, and the type of LDL circulating in your blood matters. Oxidized LDL is increasingly recognized as a contributor to heart disease, vascular disease, and stroke.
What happens when LDL cholesterol is high?
If you have a high LDL level, this means that you have too much LDL cholesterol in your blood. This extra LDL, along with other substances, forms plaque. The plaque builds up in your arteries; this is a condition called atherosclerosis.
What foods help with oxidized cholesterol?
You can lower LDL cholesterol by substituting cold-water fish, such as salmon, for meat twice a week. Salmon and other fatty, oily fish—like mackerel, herring, sardines, tuna, and more—are high in healthy polyunsaturated fats and omega-3 fatty acid, which reduce triglycerides and raise HDL cholesterol.
What does oxidized LDL cholesterol mean?
Oxidized low-density lipoprotein (LDL) is a harmful type of cholesterol that is produced in your body when normal LDL cholesterol is damaged by chemical interactions with free radicals. These and a related series of inflammatory responses can result in Arteriosclerosis atherosclerosis A condition where the arteries become narrowed and hardened. , which is the hardening of the arteries.
Why is LDL oxidized in atherosclerosis?
Oxidized low-density lipoprotein (LDL) is a potentially harmful type of cholesterol that is produced in the body when normal LDL cholesterol is damaged by chemical interactions with free radicals. Together with inflammatory responses, free radicals can result in hardening of the arteries (atherosclerosis).
How does cholesterol become oxidized?
Oxycholesterol is formed when foods containing cholesterol, such as steaks and burgers, are fried or grilled. The cholesterol these foods contain reacts with oxygen to form oxidised cholesterol, also known as oxycholesterol. Saturated and unsaturated fats in fried foods react with oxygen in a different way.