Table of Contents
How can I reduce my IgE total?
Several strategies for decreasing IgE have been developed as a possible treatment for asthma. For example, anti-IgE monoclonal antibodies such as rhuMAb-E25 and CGP 56901 block binding of IgE to its high-affinity receptor and have been shown to reduce IgE levels in humans without causing anaphylaxis.
What if IgE is high?
The blood usually has small amounts of IgE antibodies. Higher amounts can be a sign that the body overreacts to allergens, which can lead to an allergic reaction. IgE levels can also be high when the body is fighting an infection from a parasite and from some immune system conditions.
What is the IgE level of immunodeficiency?
Deficiency or low IgE is defined by an IgE concentration of less than 2.5 IU/ml thus the level mentioned would meet this definition. There is no specific immunodeficiency identified by isolated IgE deficiency and selective IgE deficiency is not included in the classification of primary immunodeficiency diseases (1).
How can IgE levels be reduced in patients with asthma?
Several strategies for decreasing IgE have been developed as a possible treatment for asthma. For example, anti-IgE monoclonal antibodies such as rhuMAb-E25 and CGP 56901 block binding of IgE to its high-affinity receptor and have been shown to reduce IgE levels in humans without causing anaphylaxis. IgE levels must be nearly completely suppressed.
What happens if you have a low IgE?
Despite the absence of a specific disease or syndrome attributed to deficient IgE, there is an association with nonallergic airway symptoms, autoimmune disease, immunodeficieny and possibly an increase in cancer (3-4). There are associations with humoral immunodeficiencies including IgA, IgG4 and IgG deficiency.
How accurate are the new methods for measuring IgE levels?
These new methods are more sensitive and, besides total IgE levels, they also detect and measure specific IgE antibodies with up to 98\% accuracy. This feature can aid in the diagnosis and management of allergies [ 19 ].