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Does Spironolactone affect HRT?
Typically, you’ll begin feminizing hormone therapy by taking the diuretic spironolactone (Aldactone) at doses of 100 to 200 milligrams daily. This blocks male sex hormone (androgen) receptors and can suppress testosterone production.
Does Spironolactone affect estrogen levels?
A 2018 systematic review of 18 studies found that spironolactone showed no significant effects on levels of estrogen, estradiol, testosterone, androstenedione, dehydroepiandrosterone sulfate, luteinizing hormone, or follicle-stimulating hormone in women.
Why is Spironolactone used for HRT?
Spironolactone or Spiro is an androgen blocker prescribed in US for feminizing hormone therapy. It works by reducing testosterone levels and by reducing body’s response to testosterone.
Can I take Spironolactone with estrogen?
by taking estrogen with an androgen blocker medicine (spironolactone) that lowers blood pressure. If you cannot take spironolactone, you can make other changes to reduce your risk. This includes other types of medicine, exercise, not smoking and changes to your diet.
Is spironolactone a hormone blocker?
Spironolactone is the most commonly prescribed anti-androgen (male hormone suppressant) for transgender women as part of their hormone therapy in the United States and Canada.
Is 50 mg of spironolactone enough for hair loss?
How much is prescribed? For hair loss, your doctor will likely prescribe a daily dose of 100 to 200 milligrams. However, they might recommend you start with 25 milligrams a day and slowly increase your dose to reduce your risk for side effects. Spironolactone sometimes causes drowsiness, so it’s best to take at night.
Can spironolactone cause low estrogen?
Spironolactone has been found in some studies to increase levels of estradiol, an estrogen, although many other studies have found no changes in estradiol levels.
What’s wrong with spironolactone?
As a diuretic, spironolactone can increase urination and induce disturbances in fluid and electrolyte balance with increased potassium levels. If potassium levels increase, anticipated symptoms would include cardiac irregularities, leg cramps, dryness of mouth, thirst, lethargy, drowsiness, and headaches.
How long does it take for spironolactone to work HRT?
The clinical benefits of spironolactone as a diuretic are typically not seen until 2–3 days after dosing begins. Likewise, the maximal antihypertensive effect may not be seen for 2–3 weeks.