Table of Contents
Are you born with the HLA-B27 gene?
The HLA-B27 gene is found in 8\% of the Caucasian population. Only about 2\% of people born with HLA-B27 will get AS. This is because the protein made by HLA-B27 works with other proteins to cause the disease in ways that we don’t understand.
What does it mean to be HLA-B27 positive?
A positive test means HLA-B27 is present. It suggests a greater-than-average risk for developing or having certain autoimmune disorders. An autoimmune disorder is a condition that occurs when the immune system mistakenly attacks and destroys healthy body tissue.
What causes HLA-B27 positive?
The presence of HLA-B27 is associated with certain autoimmune and immune-mediated diseases, including: ankylosing spondylitis, which causes inflammation of the bones in your spine. reactive arthritis, which causes inflammation of your joints, urethra, and eyes, and sometimes lesions on your skin.
Is HLA-B27 inherited from mother or father?
AS can run in families, and the HLA-B27 gene can be inherited from another family member. If you have AS and tests show you carry the HLA-B27 gene then there is a 1 in 2 chance that you could pass on the gene to any children you have.
How is the HLA-B27 gene inherited?
Does HLA-B27 cause lupus?
Immunological tests revealed that antinuclear antibody and double stranded DNA antibody were positive. The human leukocyte antigen B27 antigen was also found to be positive. We propose that development of systemic lupus erythematosus in this case may have been due to low grade chronic inflammation.
What does it mean if you are HLA B27 positive?
A positive HLA-B27 test means that the person tested is at increased risk of developing certain autoimmune diseases.
Can you have ankylosing spondylits without the HLA-B27 gene?
HLA-B27 Gene Definition. A gene called HLA-B27 is found in more than 90\% of people with ankylosing spondylitis. Thus, it is possible to have ankylosing spondylitis without having the gene, but less likely. However, having a positive test for the HLA-B27 gene does not mean that ankylosing spondylitis is present or that it will develop.
What is HLA B 27?
HLA-B27 is a genetic marker. In people with inflammatory arthritis of the spine and joints (not osteoarthritis), a positive HLA-B27 test is associated with the presence of one of a group of diseases called seronegative spondyloarthropathies.
What is ankylosing spondylitis?
What Is Ankylosing Spondylitis? Ankylosing spondylitis (AS) is a rare type of arthritis that causes pain and stiffness in your spine. This lifelong condition, also known as Bechterew disease, usually starts in your lower back. It can spread up to your neck or damage joints in other parts of your body.