Sage-Tips

Can I pass on ankylosing spondylitis to my kids?

Can ankylosing spondylitis be inherited? AS can run in families, and the HLA-B27 gene can be inherited from another family member. If you have AS and tests show you carry the HLA-B27 gene then there is a 1 in 2 chance that you could pass on the gene to any children you have.

Is ankylosing spondylitis high risk pregnancy?

According to a study published in May 2019 in the journal Arthritis Care & Research, women with AS are generally at higher risk for several adverse outcomes in pregnancy. This includes a 67 percent higher risk of their baby requiring treatment in a neonatal intensive care unit (NICU).

Can you be born with ankylosing spondylitis?

Ankylosing spondylitis has no known specific cause, though genetic factors seem to be involved. In particular, people who have a gene called HLA-B27 are at a greatly increased risk of developing ankylosing spondylitis. However, only some people with the gene develop the condition.

Is HLA-B27 positive genetic?

Genetic factors HLA-B27 is the hallmark of the genetic component of spondyloarthritides, and about 90\% of patients with AS carry this antigen. The first hospital-based reports of patients with ReA showed 60\% to 80\% positivity for HLA-B27.

Is juvenile ankylosing spondylitis curable?

Juvenile ankylosing spondylitis is a progressive disease with no cure.

How can ankylosing spondylitis be prevented?

There are no known ways to prevent ankylosing spondylitis. The condition is largely due to genetics, although you may not be aware of anyone in your family with similar symptoms.

Is it safe to get pregnant with spinal stenosis?

Having a spinal cord injury (SCI) does not affect your ability to naturally become pregnant, carry, and deliver a baby, so your decision to have children is made in much the same way as anyone else.

Does spondylosis affect pregnancy?

On the basis of these results, it is concluded that pregnancy does not constitute a risk for progression of spondylolisthesis, or for increased low-back symptoms in a woman with spondylolysis. Nor is spondylolysis, with or without olisthesis, a risk factor for pregnancy complications.

What percentage of patients with ankylosing spondylitis are HLA-B27 positive?

HLA-B27 is found in 88\% of patients with ankylosing spondylitis. The chance that an HLA-B27 patient will develop spondyloarthritis or eye disease is 1 in 4.

What is the risk of my child inheriting ankylosing spondylitis?

Risk of Inheriting Ankylosing Spondylitis. Both male and female patients who are planning a family will ask, “What is the risk of my child inheriting spondylitis?”. There is a 50\% chance that the child of one HLA-B27 positive parent will inherit the gene, but a smaller chance of actually developing spondylitis. This ranges from about 5\% to 20\%.

What is ankylosing spondylitis (AS)?

Ankylosing spondylitis (AS) is a form of inflammatory arthritis that affects the spine. The children of spondylitis patients who are HLA-B27 positive have a slightly greater risk of developing the disease, particularly if other family members have been affected. The risk is lower and less predictable for families where HLA-B27 is not present.

Does spondylitis affect the back in children?

In children, spondylitis usually starts in an ankle, knee or hip, rather than the back. Months or years later, other joints may be affected, including the spine. With treatment, most children with spondylitis are not significantly disabled.

Should I Check my Child for HLA-B27 if they have spondylitis?

The risk is lower and less predictable for families where HLA-B27 is not present. Parents requiring more specific information should seek professional genetic counseling. It is not necessary to check your child for HLA-B27, since it is only one factor that contributes to the overall risk of developing spondylitis.