Table of Contents
- 1 Does prolyl hydroxylase require vitamin C?
- 2 Does lysyl hydroxylase need vitamin C?
- 3 What is the main function of ascorbic acid as a cofactor?
- 4 What does prolyl hydroxylase Catalyse in collagen?
- 5 What is the importance of vitamin C?
- 6 Can you take vitamin C and ferrous sulfate together?
- 7 What is peptidyl prolyl hydroxylase?
Does prolyl hydroxylase require vitamin C?
2 Ascorbic acid (vitamin C) Ascorbic acid is an essential cofactor for the enzyme prolyl hydroxylase, and a deficiency of this vitamin results in accumulation of abnormal collagen.
Does lysyl hydroxylase need vitamin C?
Lysyl hydroxylases require iron and vitamin C as cofactors for their oxidation activity. There are three lysyl hydroxylases (LH1-3) encoded in the human genome, namely: PLOD1, PLOD2 and PLOD3.
How does vitamin C work as a co factor with iron?
The vitamin C and iron combine to form an iron chelate complex, which increases the solubility of iron in the small intestine, resulting in increased uptake across the mucus membranes of the duodenum. For this reason, the vitamin C must be consumed at the same time as the iron in order to be effective.
What is the main function of ascorbic acid as a cofactor?
L-Ascorbic acid (AA), also known as vitamin C, functions as a cofactor involved in the enzymatic biosynthesis of collagen, catecholamines, and peptide neurohormones and antioxidant and free radical scavengers to detoxify free radicals in the retina as well as the brain.
What does prolyl hydroxylase Catalyse in collagen?
Prolyl hydroxylase catalyzes the formation of hydroxyproline. The modification has a significant impact on the stability of collagen, the major connective tissue of the human body.
What does lysyl oxidase do?
Lysyl oxidase (LO) is a copper-dependent amine oxidase that plays a critical role in the biogenesis of connective tissue matrices by crosslinking the extracellular matrix proteins, collagen and elastin.
What is the importance of vitamin C?
Vitamin C is needed for the growth and repair of tissues in all parts of your body. It is used to: Form an important protein used to make skin, tendons, ligaments, and blood vessels. Heal wounds and form scar tissue.
Can you take vitamin C and ferrous sulfate together?
No interactions were found between ferrous sulfate and Vitamin C. This does not necessarily mean no interactions exist. Always consult your healthcare provider.
Is ascorbic acid a cofactor or coenzyme?
Ascorbic acid is an electron donor and acts as a cofactor for fifteen mammalian enzymes. Two sodium-dependent transporters are specific for ascorbic acid, and its oxidation product dehydroascorbic acid is transported by glucose transporters. Ascorbic acid is differentially accumulated by most tissues and body fluids.
What is peptidyl prolyl hydroxylase?
Prolyl hydroxylase (proline,2-oxoglutarate dioxygenase, EC 1.14. 11.2) is a mixed-function oxygenase that hydroxylates peptidyl proline with the simultaneous and stoichiometric decarboxylation of alpha-ketoglutarate to succinate and CO2.