What does it mean to be ubiquitously expressed?
For these purposes, ubiquitous expression was defined as the uniformity of expression across tissues regardless of the magnitude of expression whereas tissue-specificity was interpreted as a significant positive deviation from uniformity in one of multiple tissues.
What is a ubiquitous transcription factor?
Many transcription factors are common to several cell types (ubiquitous), such as AP-1 and NF-κB, and may play a general role in the regulation of inflammatory genes, whereas others are cell-specific and may determine the phenotypic characteristics of a cell. …
Where is Sp1 expressed?
We found that Sp1 protein was expressed predominantly in the nuclei of cells located in the mucous neck region, whereas Sp1 expression was not detected either in the cells located toward the gastric pit (foveolar differentiation) or cells of the glandular epithelium (glandular differentiation).
What is TBOX transcription factor?
T-box refers to a group of transcription factors involved in embryonic limb and heart development. Every T-box protein has a relatively large DNA-binding domain, generally comprising about a third of the entire protein that is both necessary and sufficient for sequence-specific DNA binding.
Is ubiquitously a word?
adj. existing or being everywhere, esp. at the same time; omnipresent. u•biq′ui•tous•ly, adv.
Is NF Kappab transcription factor?
Nuclear factor-kappa B (NF-κB) is a ubiquitous transcription factor that is involved in inflammatory and immune responses, as well as in regulation of expression of many other genes related to cell survival, proliferation, and differentiation.
What is the role of Sp1?
Sp1 is a ubiquitous nuclear factor that plays a key role in maintaining basal transcription of ‘house-keeping’ genes. However, recent evidence points to a more important function for Sp1 in mediating ‘cross-talk’ between selected signaling cascades to regulate the target genes that respond to these pathways.
Is Sp1 a transcription factor?
Sp1 (specificity protein 1) is a well-known member of a family of transcription factors that also includes Sp2, Sp3 and Sp4, which are implicated in an ample variety of essential biological processes and have been proven important in cell growth, differentiation, apoptosis and carcinogenesis.
What does T-box mean?
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