Sage-Tips

What is drug delivery implants?

Implantable drug delivery devices generally consist of a drug reservoir surrounded by a polymer or a drug polymer mixture [6]. When inserted into the desired area of the body, the drug will be released at a pre-determined rate as the polymer degrades.

What are advantages of implantable drug delivery system?

The major advantages of these systems include targeted local delivery of drugs at a constant rate, less drug required to treat the disease state, minimization of possible side effects, and enhanced efficacy of treatment.

What is disadvantage of implantable drug delivery system?

Drug delivery by injection has other disadvantages. Patients must choose between traveling to a treatment site and maintaining a home supply. Furthermore, the discomfort of frequent injections leads to poor patient compliance. An advanced implantable system can be used to precisely control the rate of drug delivery.

What are the characteristics of the reservoir or membrane devices?

What are the characteristics of the reservoir or membrane devices? Explanation: These devices are used when the drug permeation through the stratum corneum is rapid than the rate of drug diffusion from the device. It is suitable for drugs which have low therapeutic indices.

What is implantable drug making cells?

One day implantable cell therapies may include a broader array of cell types, including some engineered through synthetic biology—which reprograms a cell’s genetics to make it perform novel functions, such as controlled, on-demand release of specified drug molecules into a tissue.

Which is related to implantable DDS?

Implantable DDS Implantable DDSs can be used for antibiotic administration and immunization, treatment of diseases such as diabetes and bone infections. The latter can be treated via sustained release, cyclic release, multi-phase release, pulse release and the controlled release of multiple drugs.

Which of the following characteristics is suitable for transdermal drug *?

To be delivered transdermally, an ideal drug should have the following properties: low molecular weight (less than 1000 Da), affinity for lipophilic and hydrophilic phases, low melting point, have a short half-life and non-irritating.

Which of the following drug delivery system has the longest duration of action?

The present limit on duration of rate-controlled oral products is currently set by the transit of solid dosage forms through the gastrointestinal tract: the longest of the oral delivery system products has a delivery time of 18 h [7].

What are the characteristics of monolithic devices?

A software system is called “monolithic” if it has a monolithic architecture, in which functionally distinguishable aspects (for example data input and output, data processing, error handling, and the user interface) are all interwoven, rather than containing architecturally separate components.

What are the barriers in ocular drug delivery absorption?

Following systemic administration, the blood–aqueous barrier and blood–retinal barrier are the major barriers for anterior segment and posterior segment ocular drug delivery, respectively. Blood–aqueous barrier consists of two discrete cell layers located in the anterior segment of the eye viz.

Which of the following drugs are used in implants?

Which of the following drugs are used in implants? Explanation: Drugs which are generally used for such implants are steroids like contraceptives, morphine antagonists like naltrexone for opioid-dependent addicts. Polymers used for making such implants are polymethacrylates, elastomers, etc.

What are ophthalmic inserts?

Ocular inserts are defined as sterile, thin, multilayered, drug-impregnated, solid or semisolid consistency devices placed into the cul-de-sac or conjuctival sac, whose size and shape are especially designed for ophthalmic application. They are composed of a polymeric support that may or may not contain a drug.

What are implantable drug delivery devices?

Implantable drug delivery devices offer several advantages over conventional oral or parenteral dosage forms. First, implantable devices allow site specific drug administration where the drug is most needed. Examples include implants used in the treatment of brain tumors (Gliadel® wafer) or prostate cancer (Lupron® depot).

What are the key materials considerations for drug delivery?

As with all implantable devices, key materials considerations for use in drug delivery include biocompatibility, stability and durability (except in the case of biodegradable drug delivery systems), and the ability of the material to control release of the active pharmaceutical ingredient (API).

What are the advantages of implantable devices?

First, implantable devices allow site specific drug administration where the drug is most needed. Examples include implants used in the treatment of brain tumors (Gliadel® wafer) or prostate cancer (Lupron® depot). This may also allow for significantly lower doses of drug which can minimize potential side effects.

What are implantable drug pumps used for?

Implantable drug pumps are used to deliver insulin in the treatment of diabetics and to administer pain medications directly to the spine (intrathecal pumps). These are typically programmable “active” devices which require regular resupply of the medication through an access port.